Bioss Inc.'s ITPR1 (5G10) Monoclonal Antibody is a Rabbit monoclonal antibody. The ITPR1 (5G10) Monoclonal Antibody was generated using ITPR1 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)